BeyondResponse 3.5   
by BeyondResponse   

Automate your entire business with Beyond Response. An opt-in and opt-out email list management tool, BeyondResponse can be used in a large array of applications. You can use it to provide instant product delivery to your eBay and Clickbank customers, plus manage mass sending for product updates, or upselling. BeyondResponse also has bounce-back protection and information caption techniques. There is no better utility on the market that will help you manage your business.

Beyond Response is an opt-in email management system that runs on your local computer. It monitors incoming emails from your Pop3 account that you set up, and it responds to those emails based on filter criteria that you set.
Once an incoming email has met a certain criteria, Beyond Response sends out newsletters using your SMTP accounts. You can set up more than one SMTP account, and Beyond Response will cycle between them.